首页> 外文期刊>Open Access Library Journal >JAK-STAT Lodges in Multiple Sclerosis: Pathophysiology and Therapeutic Approach Overview
【24h】

JAK-STAT Lodges in Multiple Sclerosis: Pathophysiology and Therapeutic Approach Overview

机译:多发性硬化症的JAK-STAT小屋:病理生理学和治疗方法概述

获取原文
       

摘要

Multiple sclerosis (MS) is a complex inflammatory and demyelinating disease of central nervous system (CNS). The disease pathogenesis is not fully understood and no actual cure for the disease yet. The disease has genetic and environmental cause as fundamental factors which are identified for the disease pathogenesis so far. One of the characteristic features of the disease is inflammation cause due to activation of pro-inflammatory cells. Interference in signalling pathways such as JAK/STAT could result in physiological or pathological outcome in MS. Dysregulation of JAK/STAT signalling pathway is associated with chronic inflammatory process and immune disorders. In this review, considering the important role of JAK/STAT pathway in signal transduction of inflammatory process and immune responses in CNS, we describe the involvement of this signal transduction pathway in MS. Moreover, we consider the physiological and pathological involvement of JAK/STAT rout in neurogenesis/gliogenesis, cytokines production and as therapeutics target for managing MS.
机译:多发性硬化症(MS)是中枢神经系统(CNS)的复杂炎症和脱髓鞘疾病。尚未完全了解疾病的发病机理,并且尚未真正治愈该疾病。该疾病具有遗传和环境原因,是迄今为止确定为疾病发病机理的基本因素。该疾病的特征之一是由于促炎细胞的活化引起的炎症。干扰JAK / STAT等信号通路可能导致MS出现生理或病理结果。 JAK / STAT信号通路的失调与慢性炎症过程和免疫疾病有关。在这篇综述中,考虑到JAK / STAT通路在炎症过程和中枢神经系统免疫应答的信号转导中的重要作用,我们描述了该信号转导通路在MS中的参与。此外,我们考虑了JAK / STAT溃烂在神经发生/神经胶质发生,细胞因子产生中的生理和病理参与,并且是管理MS的治疗目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号