In vitro evaluation of the antimicrobial activity of N-phenylcarbamothioyl benzamides against planktonic and adherent microbial cells

摘要

A set of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)benzamides derivatives(1a-h) previously synthesized and characterized by 1H-NMR, 13C-NMR, IR, MS, and elemental analysishave been assessed for their antimicrobial activity against planktonic and adherent microbial cells. Ourresults demonstrated that the newly synthesized compounds exhibited good antimicrobial activity,especially against adherent cells, so they could be used for the development of novel antimicrobialmaterials or strategies for fighting medical biofilms frequently implicated in the etiology of chronicinfections. Taking into account that the tested compounds proved good anti-inflammatory activity, theymight be potential candidates for further pharmacological investigations, as the concept of combiningantimicrobial with anti-inflammatory activity in one compound is promising for future medical use inthe treatment of bacterial infections, especially those accompanied by pain and inflammation symptoms.