RISK FACTORS IN PANCREATIC CANCER

摘要

PREVIOUS STUDIES HAVE SHOWN A VARIETY OF RISK FACTORS THAT MAY BE INVOLVED IN THEAETIOLOGY OF PANCREATIC NEOPLASIA. WE EXAMINED RISK FACTORS FOR PANCREATIC CANCER INA CASE–CONTROL STUDY CONDUCTED IN FUNDENI CLINICAL INSTITUTE BETWEEN SEPTEMBER 2016AND SEPTEMBER 2018, THAT INCLUDED 74 INCIDENT CASES AND 74 CONTROLS ADMITTED FOR NONNEOPLASTIC DISEASES, FREQUENCY-MATCHED TO CASES BY SEX AND AGE. LOGISTIC REGRESSIONMODELS WERE USED FOR MULTIVARIATE OR SUCH AS SEX, AGE, DIABETES, VIRAL HEPATITIS, SMOKINGAND ALCOHOL CONSUMPTION STATUS, AND OTHER PERSONAL AND FAMILIAL HISTORY. OUR FINDINGSSUPPORT PREVIOUS STUDIES INDICATING THAT DIABETES IS A RISK FACTOR FOR PANCREATICCANCER (OR 4.8, P<0.05). CHOLECYSTECTOMY ALSO APPEARED TO BE A RISK FACTOR, SUBJECTS WITHA CHOLECYSTECTOMY AT LEAST 20 YEARS PRIOR TO THE DIAGNOSIS OF PANCREATIC CANCEREXPERIENCED AN INCREASED RISK, WHICH WAS MARGINALLY SIGNIFICANT. IN CONTRAST,SIGNIFICANT 2- FOLD (P<0.05) REDUCED RISK WAS ASSOCIATED WITH ALLERGIES. IN ADDITION, WEOBSERVED SIGNIFICANTLY INCREASED RISKS FOR SUBJECTS WHO SMOKED OR ARE CURRENTLYSMOKING. THIS STUDY DEMONSTRATES THE ROLE AS RISK FACTORS OF SOME ENVIRONMENTALFACTORS, PERSONAL AND FAMILIAL HISTORY, BUT THESE ASSOCIATIONS, HOWEVER, MAY BE DUE TOCHANCE SINCE THE NUMBER OF INDIVIDUALS INCLUDED IN THE STUDY IS REDUCED.