首页> 外文期刊>National Journal of Medical Research >Correlation of Hormonal Receptor and Her-2eu Expression in Breast Cancer: A Study at Tertiary Care Hospital in South Gujarat
【24h】

Correlation of Hormonal Receptor and Her-2eu Expression in Breast Cancer: A Study at Tertiary Care Hospital in South Gujarat

机译:乳腺癌中激素受体与her-2 / neu表达的相关性:南古吉拉特邦三级医院的一项研究

获取原文
       

摘要

Introduction: Breast cancer is the most common cancer in women and leading cause of cancer death in women. In India its incidence is rapidly rising. Present study was aimed to study pattern of expression of Hormone receptor and Her-2eu in invasive breast carcinoma and to correlate ER PR status and Her-2eu expression with various Clinicopathological aspects. Method: The present study was carried out in the Department of Pathology, Government Medical Collage, Surat, from the period of January 2011 to December 2011. Routine H&E staining for histological diagnosis and IHC analysis for ER, PR and Her-2eu was carried out in all cases. Result: This study includes total 58 cases of breast malignancies. 94.82% cases of invasive duct carcinoma. The age of patients ranged from 35 to 73 years of age. Majority of tumors are grade 2 (43.10%) followed by grade 3 (29.31%). ER, PR and Her-2eu expression was seen in 48.27%, 37.93% and 27.58% respectively. Triple negative cases comprised of 25.86% in our study. Significant correlation was observed between hormonal receptor status and Her-2eu expression. Conclusion: Our study of ER, PR and Her-2eu in breast carcinoma by IHC method indicates higher rates of positive expression correlated with various clinicopathological aspects. Higher number of grade 1 tumor showed ER, PR positivity as compared to grade 3 tumors. Inverse relationship was observed between Her-2eu expression and ER, PR receptor status. Her-2eu expression was increased with size and high grade of tumor. Her-2eu expression did not show any significant correlation with age.
机译:简介:乳腺癌是女性中最常见的癌症,是女性癌症死亡的主要原因。在印度,其发病率迅速上升。本研究旨在研究浸润性乳腺癌中激素受体和Her-2 / neu的表达模式,并将ER PR状态和Her-2 / neu的表达与各种临床病理因素相关联。方法:本研究于2011年1月至2011年12月在苏拉特政府医学杂志病理学系进行。常规H&E染色用于ER,PR和Her-2 / neu的组织学诊断和IHC分析。在所有情况下都进行。结果:本研究共纳入58例乳腺恶性肿瘤。浸润性导管癌94.82%。患者的年龄为35至73岁。多数肿瘤为2级(43.10%),其次为3级(29.31%)。 ER,PR和Her-2 / neu表达分别见于48.27%,37.93%和27.58%。在我们的研究中,三阴性病例占25.86%。激素受体状态与Her-2 / neu表达之间存在显着相关性。结论:我们通过IHC方法对乳腺癌的ER,PR和Her-2 / neu进行的研究表明,阳性表达率较高,与各种临床病理方面相关。与3级肿瘤相比,较高数量的1级肿瘤显示ER,PR阳性。观察到Her-2 / neu表达与ER,PR受体状态成反比关系。 Her-2 / neu表达随肿瘤的大小和高度分级而增加。 Her-2 / neu表达与年龄没有任何显着相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号