Effect of inhaled salbutamol on dynamic intrinsic positive end-expiratory pressure in spontaneously breathing patients with stable severe chronic obstructive pulmonary disease

摘要

Background: The objective was to determine the effect of inhaled salbutamolon PEEPi dyn in spontaneously breathing patients with stable severe chronic obstructive pulmonary disease(COPD). Material/Methods: Eleven patients with COPD were studied (mean age: 63 years, average FEV(1)0.71+/-0.31 L). The patients were evaluated before and after inhaling 400 g of salbutamol. Spirometry,slow vital capacity, breathing pattern, and PEEPi dyn pre- and post-bronchodilator administration wereperformed. PEEPi dyn was measured as the difference in esophageal pressure between the onset of inspiratoryeffort and the point of zero flow. Results: Pre-BD PEEPi dyn fell on average by 56% after inhalationof salbutamol (1.89+/-1.24 cm H(2)O to 0.83+/-0.81 cm H(2)O, p