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Impact of an Anticaries Mouthrinse onIn VitroRemineralization and Microbial Control

机译:防龋齿漱口水对体外再矿化和微生物控制的影响

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Objective. The objective of this research was to evaluate the caries control potential of a new fluoride mouthrinse that also contained antimicrobial agents and a biofilm disrupting agent using differentin vitromodels.Methods. Fourin vitrostudies were conducted to assess the performance of this three pronged approach to caries control: (1) traditional enamel fluoride uptake, (2) surface microhardness study using pH cycling model and subsequent fluoride uptake, (3) a salivary biofilm flow-through study to determine the anti-microbial activity, and (4) a single species biofilm model measuring effect on biofilm matrix disruption.Results. The data showed that a LISTERINE rinse with fluoride, essential oils and xylitol was superior in promoting enamel fluoride uptake and in enhancing antimicrobial activity over traditional commercially available fluoridated products. An increase of the surface microhardness was observed when the LISTERINE rinse was used in combination with fluoridated toothpaste versus the fluoridated toothpaste alone. Finally, it was demonstrated that xylitol solutions disrupted and reduced the biovolume of biofilm matrix of matureStreptococcus mutans.Conclusion. Thesein vitrostudies demonstrated that a fluoride mouthrinse with antimicrobial agent and biofilm matrix disrupting agent provided multifaceted and enhanced anti-caries efficacy by promoting remineralization, reducing acidogenic bacteria and disrupting biofilm matrix.
机译:目的。这项研究的目的是评估使用不同的体外模型的新型氟化物漱口水的龋齿控制潜力,该氟化物还含有抗菌剂和生物膜破坏剂。进行了四项体外研究,以评估这三种控制龋齿的方法的性能:(1)传统牙釉质氟化物摄取;(2)使用pH循环模型和随后的氟化物摄取进行表面显微硬度研究;(3)唾液生物膜流经研究以确定其抗微生物活性,以及​​(4)测量生物膜基质破坏作用的单一物种生物膜模型。数据显示,与传统的市售氟化产品相比,用氟化物,精油和木糖醇进行的LISTERINE漂洗液在促进搪瓷氟化物吸收和增强抗菌活性方面表现优异。当将LISTERINE冲洗液与氟化牙膏组合使用时,相对于单独的氟化牙膏,观察到表面显微硬度的增加。最后,证明木糖醇溶液破坏并减少了成熟变形链球菌生物膜基质的生物体积。这些体外研究表明,氟化物漱口水与抗菌剂和生物膜基质破坏剂共同作用,通过促进矿化作用,减少产酸细菌和破坏生物膜基质,从而提供多方面的抗龋功效。

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