LOW-DOSE OR HIGH-DOSE HYDROCHLOROTHIAZIDE IN IDIOPATHIC HYPERCALCIURIA AMONG CHILDREN. RE: ROLE OF HIGH-DOSE HYDROCHLOROTHIAZIDE IN IDIOPATHIC HYPERCALCIURIC UROLITHIASIS OF CHILDHOOD

摘要

We read with interest the article " Role of high-dose hydrochlorothiazide in idiopathic hypercalciuric urolithiasis of childhood " by Naseri and Sadeghi. They used high-dose hydrochlorothiazide (1 mg/ kg/d to 2 mg/kg/d) in hypercalciuric children and described that no study has addressed whether low doses of thiazides have a hypocalciuric effect, especially in children. We recently reported that a low dose (0.5 mg/kg/d) of hydrochlorothiazide may be safe and effective in controlling renal hypercalciuria in children and found that hematuria and urolithiasis gradually resolved in accordance with the improvement of hypercalciuria.