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Serum Prolactin Levels and the Acute-phase Efficacy in Drug-na?ve Schizophrenia Treated with Ziprasidone and Olanzapine (translated version)

机译:齐普西酮和奥氮平治疗的初治精神分裂症患者的血清催乳素水平和急性期疗效(翻译版)

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Objectives: To study the efficacy and associated serum prolactin levels of ziprasidone and olanzapine treatment in drug-na?ve schizophrenia patients. Methods: All 78 inpatients with drug-na?ve schizophrenia were recruited from the Department of Psychology, The Third Affiliated Hospital of Sun Yat-sen University. They were divided into either olanzapine group (n = 49 [24 men, 25 women]; mean [standard deviation] age, 24 [6] years) or ziprasidone group (n = 29 [14 men, 15 women]; mean [standard deviation] age, 23 [7] years), all of whom were treated for 4 weeks. The serum prolactin level, the Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression–Severity (CGI-S), and Clinical Global Impression–Improvement scores were measured before and at the end of treatment. Results: In the olanzapine group, the respective mean (standard deviation) PANSS and CGI-S scores after the treatment (62 ± 15 and 3 ± 1) were significantly lower than those before the treatment (104 ± 14 and 6± 1) [p 0.01]. In the ziprasidone group, the corresponding scores after the treatment (75 ± 20 and 4 ± 1) were also significantly lower than those before the treatment (104 ± 17 and 6 ± 1) [p 0.01]. The decreases in mean (standard deviation) PANSS total (42 ± 17) and PANSS positive scores (12 ± 6) in the olanzapine group were significantly higher than those in the ziprasidone group (29 ± 12 and 6 ± 4, respectively) [p 0.01]. The increase of serum prolactin in the ziprasidone female group (47 ± 51 μg/L) was significantly higher than that in the ziprasidone male group (17 ± 11 μg/L), the olanzapine male group (5 ± 16 μg/L), and the olanzapine female group (21 ± 34 μg/L) [p 0.05]. Conclusions: Both ziprasidone and olanzapine are effective for treating drug-na?ve acute schizophrenia, but olanzapine was superior to ziprasidone in terms of positive and general psychopathological symptoms. In women, ziprasidone was associated with greater changes in prolactin level than olanzapine.
机译:目的:研究齐拉西酮和奥氮平治疗初治型精神分裂症的疗效及相关的血清催乳素水平。方法:从中山大学附属第三医院心理系招募78例初治精神分裂症住院患者。他们分为奥氮平组(n = 49 [24名男性,25名女性];平均[标准差]年龄,24 [6]岁)或齐拉西酮组(n = 29 [14名男性,15名女性];均值[标准]年龄[23] [7]岁),所有患者均接受了4周的治疗。在治疗之前和结束时分别测量血清催乳素水平,正负综合症量表(PANSS),临床总体印象-严重度(CGI-S)和临床总体印象-改善评分。结果:在奥氮平组中,治疗后的PANSS和CGI-S平均值(标准差)分别为62±15和3±1,显着低于治疗前(104±14和6±1)[ p <0.01]。在齐拉西酮组中,治疗后的相应分数(75±20和4±1)也显着低于治疗前的分数(104±17和6±1)[p <0.01]。奥氮平组的PANSS总平均(标准差)降低(42±17)和PANSS阳性评分(12±6)显着高于齐拉西酮组(分别为29±12和6±4)[p <0.01]。齐拉西酮雌性组的血清催乳素升高(47±51μg/ L)显着高于齐拉西酮雄性组(17±11μg/ L)和奥氮平雄性组(5±16μg/ L),奥氮平女性组(21±34μg/ L)[p <0.05]。结论:齐拉西酮和奥氮平均能有效治疗未经药物治疗的急性精神分裂症,但在阳性和一般的心理病理症状方面,奥氮平优于齐拉西酮。在女性中,与奥氮平相比,齐拉西酮与催乳素水平的变化更大。

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