CYTOGENETIC STUDY OF CHROMOSOMAL ABERRATIONS ASSOCIATED WITH CHRONIC LEUKEMIA

摘要

The most common cause of death is bone marrow failure. Chromosomal analysis is essential for the diagnosis, response to treatment and prognosis of leukemia. The present study was done to know the chromosomal abbreviation in chronic leukemia of patients with in age group of 2 to 60 years. 32 male and 21 female patients have been analyzed for this study. The chosen leukemic patients were those who were reporting for bone marrow examination in the Hematology section of Pathology Department from the coastal District of Orissa.The chromosomal aberrations were taken into account in this present study and arranged in tables, Bar charts and Pie charts for comparison. Identifying the chromosomal changes in leukemic cells will help physicians to use targeted therapy, aimed at the specific genetic defect in the cancer cells responsible for leukaemia. Conventional karyotyping which shows the structural, numerical and compound aberrations have improved the genetic diagnosis of leukaemia. It forms an important platform on which pyramid of modern cyto and molecular genetics have been growing for the most accurate diagnosis of leukemia.