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Effect of clonidine and magnesium sulphate on anaesthetic consumption, haemodynamics and postoperative recovery: A comparative study

机译:可乐定和硫酸镁对麻醉剂消耗,血液动力学和术后恢复的影响:一项比较研究

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This randomised, placebo-controlled, double-blind study was designed to assess the effect of intravenous clonidine and magnesium sulphate on intraoperative haemodynamics, anaesthetic consumption and postoperative recovery. Seventy five patients undergoing elective upper limb orthopaedic surgery were randomised into three groups. Group C received clonidine 3 μg/kg as a bolus before induction and 1μg/kg/hour by infusion intraopertively. Group M received magnesium sulphate 30 mg/kg as a bolus before induction and 10 mg/kg/hour by infusion. Group P received same volume of isotonic saline. Anaesthesia was induced and maintained with fentanyl citrate and propofol. Muscular relaxation was achieved by vecuronium bromide. Induction time, recovery time and consumption of propofol as well as fentanyl citrate were recorded. Induction of anaesthesia was rapid with both clonidine and magnesium sulphate. Time of bispectral index (BIS) to reach 60 was significantly lower in Group C and Group M (P < 0.0001). Requirements of propofol and fentanyl were significantly less in Group C and Group M (P < 0.001). Postoperative recovery was slower in Group M compared with other two groups (P < 0.001). Perioperative use of both clonidine and magnesium sulphate significantly reduced the consumption of propofol and fentanyl citrate. Magnesium sulphate caused a delayed recovery.Keywords: Anaesthetic consumption, bispectral index, clonidine, magnesium sulphate
机译:这项随机,安慰剂对照,双盲研究旨在评估静脉内可乐定和硫酸镁对术中血液动力学,麻醉药消耗和术后恢复的影响。将接受选择性上肢骨科手术的75例患者随机分为三组。 C组在诱导前以3μg/ kg的剂量注射可乐定,并在术中输注1μg/ kg /小时。 M组在诱导前以大剂量推注硫酸镁30 mg / kg,并通过输注接受10 mg / kg /小时。 P组接受等体积的等渗盐水。用柠檬酸芬太尼和丙泊酚诱导并维持麻醉。溴化维库溴铵可实现肌肉松弛。记录诱导时间,恢复时间和异丙酚以及柠檬酸芬太尼的消耗。可乐定和硫酸镁均可快速诱导麻醉。 C组和M组的双光谱指数(BIS)达到60的时间显着降低(P <0.0001)。 C组和M组的异丙酚和芬太尼的需求量明显减少(P <0.001)。 M组的术后恢复较其他两组慢(P <0.001)。围手术期使用可乐定和硫酸镁可显着减少丙泊酚和柠檬酸芬太尼的消耗。硫酸镁引起延迟恢复。关键词:麻醉药消费,双光谱指数,可乐定,硫酸镁

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