首页> 外文期刊>Indian journal of Anaesthesia >Effect of 50% enantiomeric excess bupivacaine mixture combined with pancuronium on neuromuscular transmission in rat phrenic nerve-diaphragm preparation; a pilot study
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Effect of 50% enantiomeric excess bupivacaine mixture combined with pancuronium on neuromuscular transmission in rat phrenic nerve-diaphragm preparation; a pilot study

机译:50%对映体过量布比卡因混合物与泛库溴铵对大鼠神经nerve制作的神经肌肉传递的影响;初步研究

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Background and Aims: Local anaesthetics are drugs that are widely used in clinical practice. However, the effects of these drugs on the neuromuscular junction and their influence on the blockade produced by non-depolarising neuromuscular blocking drugs are still under investigation. The aim of this study was to evaluate, in vitro, the influence of a 50% enantiomeric excess bupivacaine mixture on neuromuscular transmission and neuromuscular block produced by pancuronium. Methods: Rats were distributed into three groups (n = 5) according to the drug studied namely, 50% enantiomeric excess bupivacaine mixture (5 μg/mL); pancuronium (2 μg/mL); 50% enantiomeric excess bupivacaine mixture + pancuronium. The following parameters were evaluated: (1) Effects of a 50% enantiomeric excess bupivacaine mixture on membrane potential (MP) and miniature endplate potentials (MEPPs); (2) amplitude of diaphragmatic response before and 60 min after the addition of a 50% enantiomeric excess bupivacaine mixture; the degree of neuromuscular block with pancuronium and pancuronium combined with a 50% enantiomeric excess bupivacaine mixture. Results: A 50% enantiomeric excess bupivacaine mixture did not alter the amplitude of muscle response (MP) but decreased the frequency and amplitude of MEPP. The block produced by pancuronium was potentiated by a 50% enantiomeric excess bupivacaine mixture. Conclusion: A 50% enantiomeric excess bupivacaine mixture used alone did not affect neuromuscular transmission, but potentiated the neuromuscular block produced by pancuronium. No action was shown on the muscle fibre, and alterations on MEPPs demonstrated a presynaptic action.
机译:背景与目的:局部麻醉药是在临床实践中广泛使用的药物。但是,这些药物对神经肌肉接头的作用及其对非去极化神经肌肉阻断药物产生的阻断作用的影响仍在研究中。这项研究的目的是在体外评估50%对映体过量的布比卡因混合物对泛库溴铵产生的神经肌肉传递和神经肌肉阻滞的影响。方法:根据所研究的药物将大鼠分为三组(n = 5),即50%对映体过量布比卡因混合物(5μg/ mL);潘库溴铵(2μg/ mL); 50%对映体过量的布比卡因混合物+潘库溴铵。评价以下参数:(1)50%对映异构体过量布比卡因混合物对膜电位(MP)和微型终板电位(MEPPs)的影响; (2)在添加50%对映异构体过量布比卡因混合物之前和之后60分钟的of肌反应幅度; Pancuronium和Pancuronium与50%对映异构体过量布比卡因混合物合用时的神经肌肉阻滞程度。结果:50%对映异构体过量的布比卡因混合物不会改变肌肉反应(MP)的幅度,但会降低MEPP的频率和幅度。用50%对映体过量的布比卡因混合物增强潘库溴铵产生的阻滞作用。结论:单独使用50%对映异构体过量的布比卡因混合物不会影响神经肌肉传递,但会增强潘库溴铵产生的神经肌肉阻滞作用。没有显示对肌纤维的作用,对MEPPs的改变显示出突触前的作用。

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