Inhibitory activity of a water-soluble morin derivative on phosphatase of regenerating liver-3

摘要

Morin sulphate, a novel water-soluble derivative was semi-synthesized from morin as a parent molecule. The aim of the current study was to examine the inhibitory activity of morin sulphate on the phosphatase of regenerating liver-3 (PRL-3), and its role in the metastatic potency of high metastatic ovarian carcinoma cell line (HO-8910PM)?in vitro. Morin sulphate significantly inhibited PRL-3 activity in a dose-dependent manner with an IC50?value of 1.06 μM. Furthermore, morin sulphate inhibited the invasion and migration of HO-8910PM cells,?suggesting that?it?is a PRL-3 inhibitor.