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Applied Concepts in PBPK Modeling: How to Extend an Open Systems Pharmacology Model to the Special Population of Pregnant Women

机译:PBPK建模中的应用概念:如何将开放系统药理模型扩展到孕妇的特殊人群

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This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to the pregnant populations using the Open Systems Pharmacology (OSP) software suite ( www.open-systems-pharmacology.org ). This workflow is illustrated using a previously published PBPK model for metronidazole that is extrapolated to pregnancy by parameterizing and extending the model structure in terms of pregnancy‐induced physiological changes. Importantly, this workflow can be applied to other scenarios where PBPK models need to be re‐parameterized or structurally modified.
机译:本教程介绍了使用开放系统药理(OSP)软件套件(www.open-systems-pharmacology.org)将基于成人生理学的药代动力学(PBPK)模型适应孕妇的工作流程。使用先前发布的甲硝唑PBPK模型对此工作流程进行了说明,该模型通过根据妊娠引起的生理变化参数化和扩展模型结构而推断到妊娠。重要的是,此工作流程可应用于需要重新参数化PBPK模型或对其进行结构修改的其他方案。

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