Assessment of Micronuclei Frequency in Sickled Tribal Population (Halba and Gond) of District Durg, Chhattisgarh, India

摘要

Sickle cell disease is known to induce oxidative stress which is associated with increased production of oxidizing species leading to a variety of cytogenetic abnormalities. Micronuclei formation under the influence of oxidative stress under the influence of variety of toxicants is a well known fact. In the present study micronuclei frequency among sickled tribal (Halba & Gond) population (HbAS and HbSS) among different age groups (10-20, 20-30 and 30-40 years) has been estimated and compared with the control set of population from same age groups. The frequency of micronuclei was found significantly higher in both HbAS and HbSS population of all the corresponding age groups at P >0.05. Finding of the present work emphasize on genotoxicity among sickled population confirmed by micronuclei formation under influence of oxidative stress.