Identification of the Risk Factors of Bone Metastatic among Breast Cancer Women in Al-Bashir Hospital

摘要

>Background: style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> Bone metastasis with advance cancer stage form style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">s style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> approximately 85% of all cases. Breast cancer patients frequently suffer from bone pain, functional impairment due to bone metastasis which impact style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">s>> style="font-family:""> style="font-family:Verdana;"> negatively on their quality of life. style="font-family:Verdana;">Subjects and Methods: style="font-family:Verdana;"> A retrospective study of breast cancer patients who have bone metastasis at diagnosis or developing bone metastasis during 5 years from breast cancer diagnosis (2011-2016) and who received zometa 4>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">mg monthly in radiotherapy department w style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">as style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> included and conducted in 2017. We reviewed 107 female with breast cancer diagnosed by bone scan and/or PET scan as cases of bone metastasis enrolled. Questionnaire was designed to document all variables besides, demographic data which contain (age, histopathology reading invasive ductal carcinoma,>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">invasive lobular carcinoma or others,>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">ER status, PR status, Her2neu status and l style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">y>> style="font-family:""> style="font-family:Verdana;">mph node status & stage, Onset of metastasis, Menopausal Status & finally No. of metastasis site). style="font-family:Verdana;">Results:>> style="font-family:""> style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">We noticed that the highest percentage of patients diagnosed as bone metastasis were 45 years style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> and more, style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;"> and 86% of them were invasive ductal carcinoma style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">; style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">regarding hormonal status we noticed that ER, PR status was positive in 90.7% and 82.2% of cases respectively, Her2neu receptors were amplified in 26.2% of them, positive lymph nodes style="font-family:Verdana;"> style="font-family:Verdana;"> style="font-family:Verdana;">were style="font-family