Histamine and its Effects Mediated via H3 Receptor – Potential Clinical Applications of H3 Antagonists

摘要

Histamine is one of the most important biogenic amines and it mediates numbers of physiological processes. It is also involved in majority of inflammatory diseases via its receptors H_(1), H_(2), H_(3) and H_(4). The role of histamine had been recognized as substantial in many allergic diseases including bronchial asthma, thus the histamine receptor antagonists (H_(1)) are frequently used in the clinical practice as potent anti-allergic and anti-inflammatory drugs. However, first generation of antihistamines have also adverse effects, predominantly sedation, changes in appetite and many more, and they are still not fully effective in all patients. Attention is now focused mainly on H_(3) and H_(4) receptor antagonists and their potential clinical applications. This review focuses basically on the H_(3) receptor, its expression pattern and some effects which are mediated by H_(3), discussing its clinical relevance.