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Symptom Persistence and Memory Performance in Posttraumatic Stress Disorder: A Gene X Environment Pilot Stud

机译:创伤后应激障碍的症状持久性和记忆性能:Gene X环境试验研究

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The FKBP5 gene, a glucocorticoid receptor (GR)-regulating co-chaperone of stress proteins, is of special interest because of its role in hypothalamic-pituitary-adrenal (HPA)-axis regulation. However, studies finding a genetic relationship between posttraumatic stress disorder (PTSD) and the FKBP5 gene have failed to distinguish between the development and persistence of PTSD, thereby limiting the prognostic usefulness of such a finding. The present study sought to longitudinally explore this question by examining the association between four single-nucleotide polymorphisms (SNPs) in the FKBP5 gene (rs3800373, rs9470080, rs1360780, and rs9296158), the persistence of PTSD (severity and diagnostic status), and memory performance among twenty-two treatment-seekers diagnosed with acute PTSD. Results showed that the four SNPs significantly interacted with improvement in PTSD symptoms as well as PTSD diagnostic status. Individuals homozygous for the dominant allele and having experienced higher levels of peritraumatic responses subsequently showed more memory dysfunction. The results of this study suggest that SNPs in the FKBP5 gene are associated with symptom persistence and memory dysfunction in acute PTSD.
机译:FKBP5基因是一种糖皮质激素受体(GR)调节应激蛋白的伴侣分子,由于其在下丘脑-垂体-肾上腺(HPA)轴调节中的作用而受到特别关注。但是,发现创伤后应激障碍(PTSD)和FKBP5基因之间存在遗传关系的研究未能区分PTSD的发展和持久性,从而限制了这一发现的预后价值。本研究试图通过检查FKBP5基因(rs3800373,rs9470080,rs1360780和rs9296158)中的四个单核苷酸多态性(SNP),PTSD的持续性(严重性和诊断状态)与记忆之间的关联来纵向探讨此问题22名被诊断患有急性PTSD的寻求治疗者的运动表现。结果显示,这四个SNP与PTSD症状的改善以及PTSD诊断状态显着相互作用。优势等位基因纯合并经历创伤后反应较高水平的个体随后表现出更多的记忆功能障碍。这项研究的结果表明,FKBP5基因中的SNP与急性PTSD的症状持续性和记忆功能障碍有关。

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