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Prepulse inhibition in Drosophila melanogaster larvae

机译:果蝇幼虫的脉冲前抑制

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The neural mechanisms of psychiatric diseases like autism spectrum disorder and schizophrenia have been intensively studied, and a number of candidate genes have been identified. However, the relationship between genes and neural system functioning remains unclear. Model organisms may serve as a powerful tool for addressing this question due to the availability of established genetic tools. Here, we report prepulse inhibition (PPI) inDrosophilalarvae for the first time. PPI is a neurological phenomenon found in humans and other organisms and is used in the diagnosis of schizophrenia and other psychiatric disorders. A weaker prestimulus (prepulse) inhibits the reaction to a subsequent strong, startling stimulus (pulse). Using the larval startle response to the buzz of a predator (wasp), we examined PPI in wild-type flies and two mutants: anfmr1mutant, which is implicated in Fragile X syndrome, and acentaurin gamma 1A(CenG1A) mutant, which is associated with GTPase, PH, ArfGAP, and ANK domains and implicated in autism. Both mutants showed decreased PPI, whereas, interestingly, double mutants showed substantial PPI. The PPI phenomenon described here can provide a useful tool for the study of neural mechanisms of synaptic modification and psychiatric diseases.
机译:对自闭症谱系障碍和精神分裂症等精神疾病的神经机制进行了深入研究,并鉴定了许多候选基因。但是,基因和神经系统功能之间的关系仍然不清楚。由于已建立的遗传工具的可用性,模型生物可以作为解决这一问题的有力工具。在这里,我们首次报告果蝇鼠尾草中的前脉冲抑制(PPI)。 PPI是在人类和其他生物体中发现的一种神经病学现象,用于诊断精神分裂症和其他精神疾病。较弱的前刺激(prepulse)会抑制对后续强大的,令人吃惊的刺激(pulse)的反应。使用幼虫对掠食者(wasp)嗡嗡声的惊吓反应,我们检查了野生型果蝇和两个突变体中的PPI:anfmr1mutant(与脆性X综合征有关)和acentaurinγ1A(CenG1A)突变体,与GTPase,PH,ArfGAP和ANK域,与自闭症有关。两种突变体均显示出降低的PPI,而有趣的是,双重突变体均显示出明显的PPI。这里描述的PPI现象可以为研究突触修饰和精神疾病的神经机制提供有用的工具。

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