Regulatory B cell-myeloma cell interaction confers immunosuppression and promotes their survival in the bone marrow milieu

摘要

Multiple myeloma (MM), a terminally differentiated B-cell malignancy, is characterized by excess bone marrow (BM) plasma cells and immunosuppression. At present, the role of B-cell subsets in the MM-related immune suppressive BM microenvironment is not fully characterized.