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High strength re-mineralizing, antibacterial dental composites with reactive calcium phosphates

机译:具有反应性磷酸钙的高强度再矿化,抗菌牙科复合材料

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摘要

Objective. Development of high strength dental composites with adhesive, antibacterial and re-mineralizing potential. Materials. Urethane and triethylene glycol dimethacrylates were combined with HEMA (10 or 20wt%) and 2MP (2 or 10wt%), antibacterial chlorhexidine (2.5wt%) and chemical cure initiators. Reactive mono/tri calcium phosphate (CP) mixed with silica/silicon carbide nanoparticles (S) (CP:S weight ratio 1:2 or 2:1) was added (50 wt%). Results. Decreasing CP/S ratio and HEMA content reduced monomer conversion at 15 min from 93 to 63%. Conversely, decreasing CP/S increased initial "dry" compressive (137-203 MPa) and flexural (79-116 MPa) strength. With high HEMA content, these decreased by ~15-20 MPa upon 24 h water storage. With low HEMA content, average decline was <8 MPa due to reduced water sorption. Early water sorption induced mass increase, volume expansion, mono calcium phosphate dissolution and chlorhexidine release, were proportional to the initial calcium phosphate content. Furthermore, they increased ~1.5 fold upon raising HEMA wt%. These diffusion controlled processes and strength decline slowed after 24 h as phosphates reaction bound water within the materials. Increasing 2MP concentration reduced calcium release but did not affect strength. Formulations with high CP/S indicated greater antibacterial activity in agar diffusion and in vitro biofilm tests. Significance. New material use beneath a conventional composite could potentially reduce high failure rates associated with residual caries and bacterial microleakage.
机译:目的。具有粘接,抗菌和再矿化潜力的高强度牙科复合材料的开发。材料。将氨基甲酸酯和三乙二醇二甲基丙烯酸酯与HEMA(10或20wt%)和2MP(2或10wt%),抗菌洗必太(2.5wt%)和化学固化引发剂混合。加入与二氧化硅/碳化硅纳米颗粒(S)混合的反应性磷酸单/三钙(CP)(CP∶S重量比为1∶2或2∶1)(50重量%)。结果。 CP / S比和HEMA含量的降低将15分钟时的单体转化率从93%降低至63%。相反,降低CP / S会增加初始“干”压缩强度(137-203 MPa)和弯曲强度(79-116 MPa)。 HEMA含量高时,在储存24小时后,这些含量降低了约15-20 MPa。在低HEMA含量的情况下,由于吸水率降低,平均下降<8 MPa。早期水吸附引起质量增加,体积膨胀,磷酸一钙溶解和洗必太释放,与初始磷酸钙含量成正比。此外,它们在提高HEMA wt%时增加了约1.5倍。这些扩散控制的过程和强度下降在24小时后减缓,因为磷酸盐反应将水束缚在材料中。增加2MP浓度可减少钙的释放,但不影响强度。具有高CP / S的配方表明在琼脂扩散和体外生物膜测试中具有更大的抗菌活性。意义。在常规复合材料下使用新材料可能会降低与残留龋齿和细菌微渗漏相关的高故障率。

著录项

  • 来源
    《Dental materials》 |2013年第4期|473-484|共12页
  • 作者单位

    UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK,Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, Benghazi University, Benghazi, Libya;

    UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK;

    UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK;

    UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK,WCU Research Centre o/Nanobiomedical Science, Dankook University, San#29, Anseo-dong, Dongnam-gu, Cheonan-si, Chungnam 330-714, South Korea;

    UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK,Division of Biomaterials and Tissues Engineering, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Dental composite; Nanosilica-silicon carbide; Reactive calcium phosphate; Chlorhexidine release; Antibacterial; ATR-FTIR; XRD; Compressive strength; Biaxial flexure strength; Ion release;

    机译:牙科复合材料;纳米二氧化硅-碳化硅;活性磷酸钙;洗必泰释放;抗菌;ATR-FTIR;XRD;抗压强度;双轴弯曲强度;离子释放;
  • 入库时间 2022-08-18 03:47:02

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