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Mechanical properties and modeling of drug release from chlorhexidine-containing etch-and-rinse adhesives

机译:含氯己定蚀刻和冲洗粘合剂的机械性能和药物释放模型

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摘要

Objectives. To evaluate the effects of chlorhexidine (CHX) addition in different concentrations into simplified etch-and-rinse adhesives on the ultimate tensile strength (UTS), water sorption (WS), solubility (SO) and the rate of CHX release over time. Methods. We added CHX diacetate to Ambar [AM] (FGM) and XP Bond [XP] (Dentsply) in concentrations of 0, 0.01, 0.05, 0.1 and 0.2 wt%. For UTS (n = 10 for each group), adhesive specimens were constructed in an hourglass shape metallic matrix with cross-sectional area of 0.8 mm~2. Half of specimens were tested after 24 h and the other half after 28 days of water storage in tension of 0.5 mm/min. For WS and SO (n = 10 for each group), adhesive discs (5.8 mm × 1.0 mm) were prepared into a mold. After desiccation, we weighed and stored the cured adhesive specimens in distilled water for evaluation of the WS, SO and the cumulative release of CHX over a 28-day period. For CHX release (n = 10 for each group), spec-trophotometric measurements of storage solution were performed to examine the release kinetics of CHX. We subjected data from each test to ANOVA and Tukey' test (α = 0.05). Results. XP Bond adhesive showed significantly more WS and SO and lower UTS than Ambar. In general, the addition of CHX did not alter WS, SO and UTS of the adhesives. XP showed a higher CHX release than AM (p<0.05) in all concentrations and the final amount of CHX release was directly proportional to the initial CHX concentration added to the adhesives. After 28 days of water storage, approximately 20% of CHX was released from XP and 8.0-12.0% from AM. Conclusions. Addition of CHX to commercial adhesive is a feasible method to provide a controlled release of CHX over time without jeopardizing WS, SO and UTS of the adhesives. Significance. Manufacturers should consider adding CHX to commercial adhesives to provide a controlled release of CHX over time.
机译:目标。为了评估将不同浓度的洗必泰(CHX)添加到简化的蚀刻和漂洗粘合剂中对最终拉伸强度(UTS),吸水率(WS),溶解度(SO)和CHX随时间释放的速率的影响。方法。我们向Ambar [AM](FGM)和XP Bond [XP](Dentsply)中添加了CHX二乙酸盐,其浓度为0、0.01、0.05、0.1和0.2 wt%。对于UTS(每组n = 10),将胶粘剂样品制成沙漏形金属基质,其横截面积为0.8 mm〜2。储水24小时后测试一半样品,储水28天后测试另一半,其张力为0.5 mm / min。对于WS和SO(每组n = 10),将粘合盘(5.8 mm×1.0 mm)准备到模具中。干燥后,我们称重固化的粘合剂样品,并将其保存在蒸馏水中,以评估WS,SO和CHX在28天的累积释放量。对于CHX的释放(每组n = 10),对存储溶液进行分光光度法测量以检查CHX的释放动力学。我们对每个测试的数据进行方差分析和Tukey检验(α= 0.05)。结果。与Ambar相比,XP Bond粘合剂显示出更多的WS和SO和更低的UTS。通常,添加CHX不会改变粘合剂的WS,SO和UTS。 XP在所有浓度下均显示出比AM高的CHX释放量(p <0.05),CHX释放的最终量与添加到粘合剂中的初始CHX浓度成正比。储存28天后,XP释放了约20%的CHX,AM释放了8.0-12.0%。结论。在商业粘合剂中添加CHX是一种可行的方法,可在不影响WS,SO和UTS危害的情况下提供CHX随时间的受控释放。意义。制造商应考虑在商业粘合剂中添加CHX,以控制CHX随时间的释放。

著录项

  • 来源
    《Dental materials》 |2014年第4期|392-399|共8页
  • 作者单位

    Department of Restorative Dentistry, Center of Higher Education of Campos Gerais, Ponta Grossa, Brazil;

    Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil;

    School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil;

    School of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil;

    Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, Brazil;

    Department of Chemistry, State University of Santa Catarina, Joinville, Brazil;

    Universidade Estadual de Ponta Grossa - Pos Graduacao em Odontologia, Rua Carlos Cavalcanti, 4748, Bloco M, Sala 64A - Uvaranas, Ponta Grossa, Parana 84030-900, Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Adhesives systems; Chlorhexidine; Water sorption; Solubility; Chlorhexidine release; Ultimate tensile strength;

    机译:胶粘剂系统;洗必太;吸水率溶解度洗必泰释放;极限抗拉强度;
  • 入库时间 2022-08-18 03:46:56

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