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From bench-top to chair-side: How scientific evidence is incorporated into clinical practice

机译:从台式到椅子端:如何将科学证据纳入临床实践

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Objectives. The objective of this manuscript is to describe the process through which bench-top research is incorporated into clinical practice from an evidence-based dentistry perspective. Methods. Relevant literature is reviewed to describe the translation of bench-top research to clinical practice through the steps of preclinical testing; human clinical trials; systematic review development (question development, search/screen methods, evidence synthesis, and evidence appraisal); clinical recommendation development; dissemination strategies; the role of the clinician in finding and appraising relevant evidence; barriers to implementation with strategies to overcome those barriers; and finally, the fusion of evidence with clinician experience and patient needs and preferences in clinical decision-making. Significance. Descriptions of processes, methodologies, tools, and resources are provided to help researchers and clinicians alike understand the steps that lie between bench-top research and clinical implementation. With mutual understanding of the complexity involved in translating research into practice, it is hoped that barriers to implementation can be overcome that should lead to improved patient health outcomes.
机译:目标。本手稿的目的是从循证医学的角度描述将台式研究纳入临床实践的过程。方法。回顾了相关文献,以描述通过临床前测试步骤将台式研究转化为临床实践的方法。人体临床试验;系统评价的发展(问题的发展,搜索/筛选方法,证据的综合和证据的评估);临床推荐开发;传播策略;临床医生在寻找和评估相关证据中的作用;具有克服这些障碍的战略的实施障碍;最后,将证据与临床医生的经验以及患者在临床决策中的需求和偏好相结合。意义。提供了过程,方法,工具和资源的描述,以帮助研究人员和临床医生理解台式研究和临床实施之间的步骤。通过相互理解将研究转化为实践的复杂性,人们希望能够克服实施障碍,从而改善患者的健康状况。

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