Effects of substance P on cellular signalling systems in the rat anterior pituitary

摘要

The present thesis is base don experimental data appearing in eight published papers and is dealing with cellular actions of substance P at the level of the rat anterior pituitary. The aim of the thesis was to examine substance P-modulation of intracellular signalling systems and thereby establish further experimental evidence to support a di- rect action of substance P on anterior pituitary cells. Substance P-mediated cellular signalling was studied in pituitary Plasma membranes and in anterior pituitary cell cultures enriched in Lactotrophs.