A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Bar-rier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment

Zhang Chi; Gu Zhichun; Shen Long; Liu Xianyan; Lin Houwen

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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Bar-rier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment

机译：双重靶向药物输送系统，可穿透血脑屏障并将siRNA选择性输送至神经元，以治疗阿尔茨海默氏病

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Background: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.

机译：背景：阿尔茨海默氏病（AD）是对人类最严重的威胁之一，然而，该疗法因血脑屏障和差的脑内细胞选择性而受到阻碍。

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《Current Pharmaceutical Biotechnology》 |2017年第14期|1124-1131|共8页
作者
Zhang Chi; Gu Zhichun; Shen Long; Liu Xianyan; Lin Houwen;
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作者单位

Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Pharm, Shanghai 200127, Peoples R China;

Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Pharm, Shanghai 200127, Peoples R China;

Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Cardiol, Shanghai 200127, Peoples R China;

Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Pharm, Shanghai 200127, Peoples R China;

Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Pharm, Shanghai 200127, Peoples R China;

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正文语种 eng
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关键词
Blood brain barrier; ALzheimer's disease; dual targeting; gene delivery; AD treatment; nanoparticles;

机译：血脑屏障;阿尔茨海默氏病;双重靶向;基因传递;AD治疗;纳米颗粒;

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专利

1. In vivo Evaluation and Alzheimer's Disease Treatment Outcome of siRNA Loaded Dual Targeting Drug Delivery System [J] . Zhang Chi, Gu Zhichun, Shen Long, Current Pharmaceutical Biotechnology . 2019,第1期

机译：siRNA双重靶向药物递送系统的体内评价和阿尔茨海默氏病治疗结果
2. Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease [J] . Wang Pengzhen, Zheng Xiaoyao, Guo Qian, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2018,第期

机译：通过神经元靶向纳米复合物进行全身递送BACE1 siRNA以治疗阿尔茨海默病
3. Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective. [J] . Caraci F, Molinaro G, Battaglia G, Molecular pharmacology. . 2011,第3期

机译：靶向II型代谢型谷氨酸（mGlu）受体用于治疗与阿尔茨海默氏病相关的精神病：mGlu2受体的选择性激活会放大培养的神经元的β-淀粉样蛋白毒性，而mGlu2和mGlu3受体的双重激活具有神经保护作用。
4. A New Pulmonary Drug Targeted Delivery Method for Lung Diseases Treatment: An in Silico Study [C] . FengY., HaghnegahdarA., ChenX. Bioengineering and Translational Medicine Conference . 2018

机译：一种新的肺部药物靶向肺疾病治疗方法：在硅研究中
5. Validation of the Retromer Complex as a Drug Target in the Treatment of Alzheimer's Disease [D] . Mecozzi, Vincent 2012

机译：Retromer复合物作为治疗阿尔茨海默氏病的药物靶标的验证
6. Systemic enzyme delivery by blood-brain barrier-penetrating SapC-DOPS nanovesicles for treatment of neuronopathic Gaucher disease [O] . Ying Sun, Benjamin Liou, Zhengtao Chu, 2020

机译：透过血脑屏障的SapC-DOPS纳米囊泡的全身性酶递送用于治疗神经性戈谢病
7. Design of Targeted Metal Chelation Therapeutics Nanocapsules as Colloidal Carriers and Blood-Brain Barrier (BBB) Translocation to Targeted Deliver Anti-Cancer Nano Drugs into the Human Brain to Treat Alzheimer's Disease under Synchrotron Radiation [O] . Alireza Heidari 2017

机译：靶向金属螯合治疗纳米胶囊的设计作为胶体载体和血脑屏障（BBB）易位，靶向将抗癌纳米药物输送到人脑中，以治疗同步辐射下的阿尔茨海默病

A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Bar-rier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment

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