Editorial [Hot Topic: Anti-Amyloidogenic/Protein-Misfolding Therapies in Amyloidosis and Other Protein-Misfolding Disorders (Executive Editor: Masahito Yamada)]

摘要

Amyloidosis is a pathological condition where proteins with diverse chemical composition are extracellularly deposited asfibrils in the brain, heart, kidney, liver, pancreas, nerves, and other tissues or organs resulting in their serious dysfunctions.Misfolding or conformational changes of normally soluble proteins lead to pathological deposition of fibrillar proteins with across--pleated configuration. In addition to amyloidosis characterized by extracellular fibril deposition, protein-misfolding orconformational disorders include diseases characterized by intracellular deposition of fibrillar structures (inclusion bodies) suchas Lewy body diseases [Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)] and polyglutamine diseases of thebrain.