Current Issues in Tumor Immunology

摘要

The goal of tumor immunology is to understand the interactions between tumor cells and immune system, andnultimately to devise immune basedapproaches to fight cancer. We discuss here recent advances in tumor immunology andnin the interaction between immunology and informatics that provide new perspectives for the development of cancer therapy.nCancer immunoprevention is a novel approach to cancer prevention through the use of vaccines and other immunologicalnstrategies to be applied before tumor onset. The efficacy of cancer immunoprevention has been demonstrated innseveral experimental systems, however, as frequently happens in novel approaches, cancer immunoprevention studies incorporatena large number of variables. We show here how a specifically designed lattice gas model can provide significantninsight for the analysis of immune variables and the design of new biological experiments. A second approach that providesnnew perspectives in tumor immunology as the result of interactions between immunology and informatics is the usenof DNA microarrays to investigate and monitor tumor-host relationships and modifications induced by immunopreventivenand immunotherapeutic interventions.