Progress onAmpC β-lactamases

摘要

The predominant mechanism for resistance to -lactam antimicrobial agents in gram-negative bacteria is thesynthesis of -lactamases, which are capable of hydrolyzing -lactam ring. AmpC -lactamases which are termed classC/group 1, by mutation, are one of the most important -lactamases in gram-negative bacteria. They provide resistance tooxyimino-, 7--methoxy- cephalosporins and monobactams, however, are not blocked by commercially available inhibitors.In recent 10 years, the resistant mechanism of plasmid-mediated AmpC -lactamases has been more and more commonin the world. The transferability of the resistance genes can result in the nosocomial dissemination of resistantstrains, which is serious challenge to the treatment of seriously mortal infection. Therefore, progression of AmpC -lactamases is described from six aspects in the mini-review, including: a brief development history, molecular characteristics, structure, function, and regulatory mechanisms, molecular epidemiology, detection, treatment. It isprobably useful of the reasonable choice of antimicrobial agents, powerful monitoring of bacterial resistance, and thefurther study on resistant mechanism.