A learning automata-based blood glucose regulation mechanism in type 2 diabetes

摘要

This paper proposes a learning automata-based mechanism for blood glucose regulation in type 2 diabetics. The proposed mechanism takes into account the past history of the blood glucose level to determine the correct dosage of the insulin. This method uses the learning automata theory to predict the required dosage of insulin and records the patient history in parameters of a Gaussian probability distribution function. The parameters of the distribution function are updated based on the difference between the actual glucose level regulated by the learning automata and the normal range in such a way that the gap between the actual glucose level and the normal one is minimized. As the proposed algorithm proceeds, it can be seen that it converges to the optimal insulin dosage that keeps the glucose level in normal range for a long time. Convergence of the proposed algorithm to the optimal insulin dosage is theoretically proven. A clinical study is conducted to show the performance of the proposed insulin therapy system for regulation of the blood glucose level of type 2 diabetics.