Modeling and design of transdermal drug delivery patches containing an external heating device

摘要

Process modeling and design concepts were implemented to aid in the manufacturing of heat-enhanced transdermal drug-delivery systems. The simulated prototype consists of a corticosterone-loaded polymer patch applied to the skin and connected to a heating device in which an exothermic reaction occurs. To achieve a desired transdermal flux of 1.2 x 10~5 mg/cm2 h, this contribution focuses on the influences of the (1) initial reaction rate (-r_(AO)A0), (2) mass of filler material in the device (m), (3) initial concentration (Co) of medicament in the patch and (4) overall heat transfer coefficient (U). A regression technique yielded the following results:-r_(AO) = 3.000x 10~(-2) kg/m~3s,m = 1.251 × 10~(-8)kg, l/=6.124x 10J/m~2Ksand C_0 -1.966 × 10~(-1) kg/m~3. When m was fixed at 12.5g, the optimum design required the following specifications: r_(AO)=2.765× 10~(-2)kg/m~3 s,U= 1.402 × 10~3J/m~2 Ks and Co = 1.941 × 10~(-1) kg/m~3. The priority (Si) of the input factors (i) in reaching the target delivery rate is: S_(Co) > S_(rAO) > S_m > S_U.