Three-dimensional analysis for radio-frequency ablation of liver tumor with blood perfusion effect

摘要

Increase of temperature above 50 ～ 60℃ for few minutes by the emitted radio-frequency (RF) energy has been shown to be able to denaturate the intracellular proteins and destruct membranes of tumor cells. To improve the efficacy of this thermal therapy, it is important to investigate factors that may affect the RF heating characteristics for the hepatocellular carcinoma and metastatic liver tumors. In order to make sure the applied RF energy is adequate to ablate the target tumor, a 3D thermoelectric analysis for the system consisting of liver, liver arteries and 4mm diameter tumor is conducted. The effect of blood perfusion is addressed in this study.