The Design and Synthesis of a Herbicide Targeted Library of N-[1-(1,3- Benzoxazol-2-yl)Alkyl]-6-Alkyl-1,3,5-Triazine-2,4-Diamines

摘要

Amino acids were immobilised by attaching them via a carbamate linker to Wang resin. Thesenintermediates were converted to1-(1,3-benzoxazol-2-yl)alkanamines over three steps, followed by couplingnwith 4-alkyl-6-chloro-1,3,5-triazine-2-amines to furnish the desired N-[1-(1,3-benzoxazol-2-yl)alkyl]-6-alkyl-n1,3,5-triazine-2,4-diamines. Physico-chemical property profiles were used to support design and developmentnof a combinatorial library. The synthetic methodology described herein was validated with the production of anherbicide targeted library of 300 members.