Diluted Russel viper-venom time improves identification of antiphospholipid syndrome in a lupus anticoagulant-positive patient population

摘要

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the association of clinical manifestations, thrombosis and/or pregnancy morbidity, associated with the presence of antiphospholipid antibodies (APLA), including antibodies directed towards anionic phospholip-ids, phospholipid-protein complexes and also against plasma protein cofactors such as beta2-glycoprotein-1. However, actually the laboratory markers for APS include lupus anticoagulant (LA), anticardiolipin antibodies (ACLA), and anti-beta2-glycoprotein-1 antibodies (AB2GPA). Nevertheless, the main problem remains the lack of specificity and standardisation of tests for immunological markers of the disease, as they can also be found in other autoimmune and non-autoimmune diseases.