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ZMM proteins during meiosis: Crossover artists at work

机译:减数分裂过程中的ZMM蛋白:跨界艺术家在工作

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Faithful segregation of homologous chromosomes (homologs) during meiosis depends on chiasmata which correspond to crossovers between parental DNA strands. Crossover forming homologous recombination takes place in the context of the synaptonemal complex (SC), a proteinaceous structure that juxtaposes homologs. The coordination between molecular recombination events and assembly of the SC as a structure that provides global connectivity between homologs represents one of the remarkable features of meiosis. ZMM proteins (also known as the synapsis initiation complex = SIC) play crucial roles in both processes providing a link between recombination and SC assembly. The ZMM group includes at least seven functionally collaborating, yet structurally diverse proteins: The transverse filament protein Zip1 establishes stable homolog juxtaposition by polymerizing as an integral component of the SC. Zip2, Zip3, and Zip4 likely mediate protein–protein interactions, while Mer3, Msh4, and Msh5 directly promote steps in DNA recombination. This review focuses on recent insights into ZMM functions in yeast meiosis and draws comparisons to ZMM-related proteins in other model organisms.
机译:减数分裂过程中同源染色体(同源物)的正确分离取决于与父体DNA链之间的交叉对应的Chismata。交联形成同源重组发生在突触复合物(SC)的背景下,突触复合物(SC)是与同源物并列的蛋白质结构。分子重组事件和SC组装之间的协调,是一种提供同源物之间全局连接的结构,代表了减数分裂的显着特征之一。 ZMM蛋白(也称为突触起始复合物= SIC)在这两个过程中都起着至关重要的作用,提供了重组和SC组装之间的联系。 ZMM组包括至少七个功能上协作但结构上不同的蛋白质:横向细丝蛋白质Zip1通过聚合作为SC的组成部分而建立稳定的同源性并列。 Zip2,Zip3和Zip4可能介导蛋白质之间的相互作用,而Mer3,Msh4和Msh5直接促进DNA重组的步骤。这篇综述着重于对酵母减数分裂中ZMM功能的最新见解,并与其他模型生物中与ZMM相关的蛋白质作了比较。

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