首页> 外文期刊>Chinese science bulletin >Purification of β-adrenergic receptors from Beijing duck erythrocyte plasma membranes and their reconstitution with Gs and adenylate cyclase on asolectin liposomes
【24h】

Purification of β-adrenergic receptors from Beijing duck erythrocyte plasma membranes and their reconstitution with Gs and adenylate cyclase on asolectin liposomes

机译:北京鸭红细胞质膜中β-肾上腺素受体的纯化及其与Gs和腺苷酸环化酶在芦荟素脂质体上的重构

获取原文
获取原文并翻译 | 示例
       

摘要

Catecholamines such as adrenaline, norepinephrine and isoproterenol regulate a wide variety of physiological responses via their specific binding to adrenergic receptors located in the plasma membrane. Adrenergic receptors have been divided into two major types, α and β. Binding of ligands to β-adrenergic receptors (β-AR) first triggers the activation of stimulatory GTP-binding protein (Gs). The activated Gs then interacts with adenylate cyclase at the intracellular face of the plasma-membrane to stimulate the formation of cAMP, an important intracellular messenger in animal cells, which regulates a variety of biochemical and physiological functions including carbohydrate, lipid and nucleic acid metabolism, as well as synaptic transmission, ion channel function and transcription.
机译:儿茶酚胺,例如肾上腺素,去甲肾上腺素和异丙肾上腺素,通过与质膜上的肾上腺素能受体特异性结合,调节多种生理反应。肾上腺素能受体分为两种主要类型,α和β。配体与β-肾上腺素受体(β-AR)的结合首先触发刺激性GTP结合蛋白(Gs)的激活。然后,活化的Gs在质膜的细胞内表面与腺苷酸环化酶相互作用,刺激cAMP的形成,而cAMP是动物细胞中的重要细胞内信使,它调节多种生化和生理功能,包括碳水化合物,脂质和核酸代谢,以及突触传递,离子通道功能和转录。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号