Dynamic study of nitric oxide and endothelin-1 during endotoxin shock and effects of their antagonists on hemodynmamics

摘要

Conclusions Both NO and ET-1 increase during endotoxic shock, but only the increase of NO has a close temporal correspondence with the decrease of blood pressure. It suggests a more important role of NO in pathogenesis of endotoxic shock. The increase of NO and ET-1 is different in time-process, which indi- cates that an offset of their opposite vasoactive effects would not occur. Intreference against the increase of NO and ET-1 during endotoxic shock is most beneficial When their baseline levels are maintained.