Pharmacological Action of Adenophora Polysaccharides

摘要

Adenophora polysaccharides (AP), is an active principle extracted from the root of Adenophorae Potaninii Korsh originated in Gansu Province and isolated with boiling water. AP is isolated and purified from the crude drug by DEAE-cellulose and Sephadex G-200 column, with a white powder and mean molecular weight of 8. 3X10~4, and [α]D~(20) of AP is + 68. AP is only composed of glucose judging from the analysis of it with patina chromatography (PC) and gas chroma tography-mass spectrometer (GC-MS) methods. The methylation analysis showed that AP is composed of (1→6) linked glucose residues. The measure of nuclear magnetic resonance imaging (NMR) ~1H NMR and ~(14)C NMR techniques further proved that AP is α(1→6) linked by D-glucose.