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Effect of Yufeining on Induced Sputum Interleukin-8 in Patients with Chronic Obstructive Pulmonary Disease at the Stable Phase

机译:郁肺宁对稳定期慢性阻塞性肺疾病患者诱导痰白细胞介素8的影响

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摘要

Objective: To evaluate the effect of Yufeining, a traditional Chinese medicine, on induced sputum interleukin-8 (IL-8) in patients with chronic obstructive pulmonary disease (COPD) at the stable phase. Methods: Thirty-six patients with COPD were divided into trial group (18 cases) and control group (18 cases) randomly. The trial group was treated with Yufeining pills taken orally for half a year; the control group was not given any medicine. Routine lung function was recorded before and after treatment. Total cell count (TCC), differential cell counts (DCCs) and IL-8 in induced sputum were determined at the baseline and 6 months later. Results: The indices of lung function improved significantly after 6 months' treatment in trial group (P < 0.05); TCC and absolute neutrophil count decreased significantly compared with baseline in the trial group (P < 0.05); Sputum IL-8 concentration dropped significantly after 6 months' treatment, from a mean of 5.216 ± 2.914 μg/L to 4.222 ± 2.140 蘥/L (P < 0.05). There were insignificant changes in the parameters in the control group between baseline and 6 months later. Conclusion: Yufeining could improve lung function, decrease sputum TCC, absolute neutrophil count and IL-8 concentration, and relieve airway inflammation in patients with COPD in the stable phase.
机译:目的:评价中药郁肺宁对稳定期慢性阻塞性肺疾病(COPD)患者诱导痰白细胞介素8(IL-8)的影响。方法:将36例COPD患者随机分为试验组(18例)和对照组(18例)。试验组口服鱼飞宁丸治疗半年。对照组未服用任何药物。记录治疗前后的常规肺功能。在基线和6个月后确定诱导痰中的总细胞数(TCC),差异细胞数(DCC)和IL-8。结果:试验组治疗6个月后,肺功能指标明显改善(P <0.05)。与基线相比,试验组的TCC和绝对中性粒细胞计数显着下降(P <0.05);治疗6个月后,痰中IL-8浓度从5.216±2.914μg/ L的平均值下降至4.222±2.140蘥/ L(P <0.05)。在基线至6个月后,对照组的参数无明显变化。结论:郁肺宁可以改善COPD患者稳定期的肺功能,降低其痰中TCC,绝对中性粒细胞计数和IL-8浓度,缓解气道炎症。

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