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Effects of Total Flavone of Abelmoschl Manihot L. Medic on the Function of Platelets and Its Mechanism

机译:黄芪总黄酮对血小板功能的影响及其机制

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Objective: To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism. Methods: Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca~(2+)]i] was assayed by Fura-2 method. Results: TFA (25, 50, 100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0.025, 0.05, 0.1 mg/ ml) possessed dose-dependant inhibitory effects on rabbits' platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl_2-induced increase of free intracellular calcium concentration ([Ca~(2+)]i) in rabbit platelet in vitro. Conclusion: TFA has an antiplatelet effect via the inhibition on the influx of Ca~(2+).
机译:目的:研究总黄酮(Abelmoschl Manihot L. Medic,TFA)对血小板功能的影响,并探讨其作用机理。方法:使用绕过血栓形成的大鼠静脉模型。收集兔的血小板。胶原蛋白诱导血小板聚集,Fura-2法测定细胞内钙离子浓度[[Ca〜(2 +)] i],结果:TFA(25、50、100 mg / kg)显着且剂量依赖性降低。 TFA(0.025,0.05,0.1 mg / ml)对胶原蛋白诱导的兔血小板聚集具有剂量依赖性的抑制作用。TFA显着降低了静息和CaCl_2诱导的游离细胞内钙浓度的增加([Ca〜(结论:TFA通过抑制Ca〜(2+)的流入而具有抗血小板作用。

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