Effects of Chinese Kidney-Tonifying Herbal Medicine on M-Cholinergic Receptor and Acetylcholinesterase Activity in Dementia Mimetic Mice

摘要

Objective: In order to study the effects of Chinese Kidney-tonifying (KT) herbal medicine on the M-cholinergic receptor(M-R) and the acetylcholinesterase(AchE) activity in the models' cerebral cortex. Methods: Dementia mimetic mice models were formed with aluminum chloride. Results: The Muscarine receptor total receptor concentration (M-Rt) lowered and the AchE increased in the model significantly compared with healthy young mice. KT could markedly reduce the increase of AchE and elevate the lowered M-Rt in cerebral cortex of the dementia mimetic mice and improve the memory. Conclusions: KT is effective in preventing the degeneration of cerebral function and presenile dementia.