Combined Intermittent Regimens in the Treatment of Non-Miliary Pulmonary Tuberculosis: A Comparison of Streptomycin Every Third Day and Para Aminosalicylic Acid Daily with Streptomycin Every Third Day and Para Aminosalicylic Acid Every Third Day

摘要

In a previous report the Fitzsimons Group presented its ex-nperience with a regimen employing streptomycin (SM) 1 or 2ngrams intramuscularly every third day given simultaneously withnpara-aminosalicylic acid (PAS) 12 grams daily by mouth for 120ndays.”2 It was found that this combined intermittent treatmentnschedule was superior in most major aspects to regimens employ-ning SM alone daily or every third day, or PAS alone daily. Thensuppression of bacterial resistance to both drugs when SM wasngiven every third day with PAS daily for periods up to 120 daysnwas especially gratifying. As the effectiveness of this regimennbecame apparent, study of a dosage schedule combining SM 1 orn2 grams with PAS 12 grams, each every third day, was begun onnsimilar types of patients for a like period. Specifically it wasndesired to learn if the employment of PAS every third day wouldnbe as successful as PAS daily In the preservation of bacterialnsensitivity to SM without reduction of clinical or roentgenographicnresponse, since the administration of PAS every third day wouldnmeet with considerably wider patient acceptance than the dailyndosage schedule.