Estimating the acute effects of ambient ozone pollution on the premature rupture of membranes in Xinxiang, China

摘要

While increasing evidence suggests that ozone (O-3) exposure is associated with adverse birth outcomes, only one study has focused on its impact on the premature rupture of membranes (PROM). Therefore, we thus examined the effect of O-3 on PROM in Xinxiang, China, using an over-dispersed Poisson generalized additive model. Several confounding factors, including meteorological factors, temporal trends, the day of the week, and public holidays, were considered in the model. We identified a total of 3255 instances of PROM from January 1, 2015 to December 31, 2017, and there was a significant association between the daily maximum 8-h mean concentrations (O3-8h) and PROM. Each 10 mu g/m(3) increase in the 3-day average concentration (lag02) of O3-8h corresponded to an increment in PROM of 5.42% (95% CI: 1.45 -9.39%). Although the results of the stratified analyses were insignificant, a few trending results were observed: stronger associations between O-3 and PROM would occur in women with advanced age (= 35) or during the warm season than those in younger women (35) or during the cool season. Our study indicates that O-3 exposure is an important risk factor of PROM and should be considered in its prevention and control in the study area. (C) 2019 Elsevier Ltd. All rights reserved.