Diverted Domino Reactivity in Tertiary Skipped Diynes: A Convenient Access to Polyfunctionalized Cyclohexadienones and Multivalent Aromatic Scaffolds

摘要

Diverting is the game! A new domino manifold has been implemented for the synthesis of cyclohexadienone-based scaffolds from tertiary skipped diynes and secondary amines. The manifold takes advantage of a new O-enolate-driven reactivity pattern discovered for these diynes. The scaffolds are conveniently transformed into the corresponding multivalent salicylate derivatives (see scheme).