The Biosynthesis of Carbocyclic Nucleosides

摘要

Carbocyclic nucleosides are naturally occurring secondary metabolites produced by certain prokaryotic organisms. Aris-teromycin (1), the carbocyclic analogue of adenosine (2), was first isolated in 1967, from Streptomyces citricolor, having been previously synthesized in racemic form. Neplanocin A (3), and some closely related compounds, were subsequently identified in 1981 from cultures of Ampullariellaregularis. Recently, neplanocin A has been shown to be co-produced alongside aristeromycin by Streptomyces citricolor. Other related carbocyclic nucleosides, e.g. adecypenol (4), have been isolated more recently from Streptomyces spp.