Palladium-catalysed carbonylative cross-coupling reactions between an aryl halide (or pseudohalide) and an aryl metal of group IIB, IIIA, or IVA (Scheme B) can be carried out under mild conditions, in particular using low carbon monoxide pressures. Many challenges remain, such as developing applications for the synthesis of biologically active molecules. Indeed, this carbonylative aryl cross-coupling has been much less developed than that of vinyl moieties, which has been used for the synthesis of important intermediates for the synthesis of sophisticated molecules such as a capnellene derivative. In addition, the development of less expensive catalytic systems for these carbonylative coupling processes is always of interest. Nevertheless, what remains the ultimate goal of this research area is the selective synthesis of dissymmetrical diarylketones from two aryl halides (e.g., an aryliodide and an arylbromide) or an aryl halide and an aryl pseudohalide (triflates) (Scheme C) without using expensive and potentially hazardous arylmetal auxiliaries.
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