Transannular Interactions in Difunctional Medium Rings- Modelling Bimolecular Reactions

摘要

A bimolecular reaction is conveniently characterized by an energy diagram which summarizes mechanistic, structural, and energetic aspects (Figure 1). While educts (starting materials) and products as stable compounds can be analysed precisely, it is difficult to obtain information on the transition state and all other points. Alicyclic molecules of medium ring size (8—12 membered rings) are puckered, and in some conformations certain ring atoms may be quite close to each other. This may cause transannular interactions and reactions of functional groups. In such compounds it is possible to study the properties of these functional groups and their mutual interactions at distances close to those found in the transition state of the analogous bimolecular reaction (Figure 2).