Inhibitors of Glycosphingolipid Biosynthesis

摘要

Glycosphingolipids are membrane components of eukaryotic cells. They participate in various biological events and can regulate enzymes and receptors within the plasma membrane. Inhibitors of various stages of their biosynthesis have been isolated from natural sources or have been generated by design and chemical synthesis. They serve as valuable tools in the investigation of the physiological function of sphingolipids. Potential applications of these inhibitors are discussed in this article.