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Chiral Discrimination by Modified Cyclodextrins

机译:修饰环糊精的手性鉴别

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It is apparent from the work reviewed here that the naturally occurring cyclodextrins show only limited enantioselectivity in their interactions with chiral guests, because they form inclusion complexes in which there is only minimal interaction between chiral centres of the cyclodextrin and chiral substituents of the guests. As the extent of interaction between these groups is increased, as a result of modification to the cyclodextrin, the stereo-selectivity is often increased. The immediate result of this improved stereoselectivity is that, whereas separation of racemic guests using the naturally occurring cyclodextrins requires multiple interactions between the host and guest, more efficient, practical and larger-scale resolutions should be possible with the modified cyclodextrins.
机译:从这里审查的工作中显而易见的是,天然存在的环糊精在它们与手性客体的相互作用中仅显示出有限的对映选择性,因为它们形成了包合物,其中环糊精的手性中心与客体的手性取代基之间仅有最小的相互作用。随着这些基团之间相互作用程度的增加,由于对环糊精的修饰,常常增加了立体选择性。这种改善的立体选择性的直接结果是,使用天然存在的环糊精分离外消旋客体需要宿主和客体之间的多次相互作用,而使用修饰的环糊精应该可以实现更有效,实用和大规模的分离度。

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