En route to supramolecular functional plasticity: artificial β -barrels, the barrel-stave motif, and related approaches

摘要

This review emphasizes recent or pertinent efforts to create functional plasticity with artificial barrel-stave supramole- cules and related motifs. On the structural level, a summary of engineered, de novo designed, and artificialβbarrels beyond peptide chemistry is followed by representative α- helix bundles and barrel-stave supramolecules comprising oligonucleotides, inorganic architecture, and organic bar- rel-stave ion channel models.