Atropisomerism, biphenyls and the Suzuki coupling: peptide antibiotics

摘要

The formidable synthetic challenge posed by the vancomy- cin class of glycopeptide antibiotics has only recently been met. Foremost among the difficulties associated with the synthesis of these molecules is the control of non-conven- tional stereochemical issues. These are a consequence of the molecules possessing biphenyl and biaryl ether linkage between amino acid residues situated within the constituent macrocycles.