Novel hybrid vesicles co-assembled from a cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release

摘要

This work presents an important example of novel hybrid vesicles with pH-triggered transmembrane channels prepared by co-assembly of poly(acrylic acid)-g-pory(monomethoxy ethylene glycol) (PAAc-g-mPEG) with a cationic lipid, didodecyldimethylammonium bromide (DDAB), via electrostatic interaction for effective doxorubicin (DOX) release.